Gene information
Official symbol ERBB4
Official full name erb-b2 receptor tyrosine kinase 4
Gene type protein-coding gene
Chromosome2q34
Alias symbolALS19; HER4
Gene familyErb-b2 receptor tyrosine kinases; MicroRNA protein coding host genes
Resources
Entrez Gene 2066
HGNC HGNC:3432
Ensembl ENSG00000178568
Vega OTTHUMG00000133012
UCSC uc002veg.2
GO terms: 95 records
GO Description Category LogP Number of genes Detail
GO:0001655 urogenital system development GO Biological Processes -19.5104956 58 More
GO:0001667 ameboidal-type cell migration GO Biological Processes -17.0771232 40 More
GO:0001755 neural crest cell migration GO Biological Processes -8.06132628 15 More
GO:0001822 kidney development GO Biological Processes -16.2664835 49 More
GO:0002009 morphogenesis of an epithelium GO Biological Processes -21.4354199 71 More
GO:0004672 protein kinase activity GO Molecular Functions -2.03527804 36 More
GO:0006468 protein phosphorylation GO Biological Processes -5.36604576 56 More
GO:0007005 mitochondrion organization GO Biological Processes -2.05283627 29 More
GO:0007167 enzyme-linked receptor protein signaling pathway GO Biological Processes -26.8285253 93 More
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway GO Biological Processes -16.7048742 60 More
GO:0007389 pattern specification process GO Biological Processes -10.9656233 30 More
GO:0007416 synapse assembly GO Biological Processes -2.37502879 6 More
GO:0007420 brain development GO Biological Processes -11.5572036 75 More
GO:0007507 heart development GO Biological Processes -29.3002557 91 More
GO:0007589 body fluid secretion GO Biological Processes -11.5155091 20 More
GO:0007595 lactation GO Biological Processes -4.29648227 9 More
GO:0008285 negative regulation of cell population proliferation GO Biological Processes -53.5569125 147 More
GO:0008637 apoptotic mitochondrial changes GO Biological Processes -5.28671514 12 More
GO:0009880 embryonic pattern specification GO Biological Processes -3.03291013 6 More
GO:0014032 neural crest cell development GO Biological Processes -11.9399165 15 More
GO:0014033 neural crest cell differentiation GO Biological Processes -12.2997127 24 More
GO:0014066 regulation of phosphatidylinositol 3-kinase signaling GO Biological Processes -15.9250248 30 More
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling GO Biological Processes -18.2876323 28 More
GO:0019199 transmembrane receptor protein kinase activity GO Molecular Functions -5.31743835 14 More
GO:0021537 telencephalon development GO Biological Processes -6.21909725 29 More
GO:0030855 epithelial cell differentiation GO Biological Processes -14.2408795 69 More
GO:0030879 mammary gland development GO Biological Processes -8.79064244 23 More
GO:0030900 forebrain development GO Biological Processes -11.1545964 48 More
GO:0033674 positive regulation of kinase activity GO Biological Processes -29.8538991 87 More
GO:0034329 cell junction assembly GO Biological Processes -3.18336526 12 More
GO:0034330 cell junction organization GO Biological Processes -7.96624809 49 More
GO:0038127 ERBB signaling pathway GO Biological Processes -2.50267494 8 More
GO:0040007 growth GO Biological Processes -14.0580178 53 More
GO:0040008 regulation of growth GO Biological Processes -30.7609323 104 More
GO:0042734 presynaptic membrane GO Cellular Components -4.19875640 10 More
GO:0042803 protein homodimerization activity GO Molecular Functions -14.2815375 77 More
GO:0043408 regulation of MAPK cascade GO Biological Processes -57.2547066 142 More
GO:0043410 positive regulation of MAPK cascade GO Biological Processes -49.4744054 112 More
GO:0043549 regulation of kinase activity GO Biological Processes -36.8507249 123 More
GO:0045165 cell fate commitment GO Biological Processes -15.5778047 44 More
GO:0045211 postsynaptic membrane GO Cellular Components -5.83105498 30 More
GO:0045927 positive regulation of growth GO Biological Processes -20.3035639 52 More
GO:0046425 regulation of receptor signaling pathway via JAK-STAT GO Biological Processes -10.5317026 20 More
GO:0046620 regulation of organ growth GO Biological Processes -13.2396968 26 More
GO:0046622 positive regulation of organ growth GO Biological Processes -9.67012229 16 More
GO:0046903 secretion GO Biological Processes -18.5147167 70 More
GO:0048589 developmental growth GO Biological Processes -14.0580178 53 More
GO:0048638 regulation of developmental growth GO Biological Processes -23.5012496 63 More
GO:0048639 positive regulation of developmental growth GO Biological Processes -14.4198804 35 More
GO:0048729 tissue morphogenesis GO Biological Processes -31.7796969 96 More
GO:0048732 gland development GO Biological Processes -26.3979320 74 More
GO:0048762 mesenchymal cell differentiation GO Biological Processes -16.1250183 37 More
GO:0048863 stem cell differentiation GO Biological Processes -16.2106470 36 More
GO:0048864 stem cell development GO Biological Processes -12.7283120 16 More
GO:0050730 regulation of peptidyl-tyrosine phosphorylation GO Biological Processes -27.1120967 60 More
GO:0050808 synapse organization GO Biological Processes -6.17744712 32 More
GO:0051347 positive regulation of transferase activity GO Biological Processes -26.6059528 90 More
GO:0055021 regulation of cardiac muscle tissue growth GO Biological Processes -9.70685856 18 More
GO:0055023 positive regulation of cardiac muscle tissue growth GO Biological Processes -8.77845673 13 More
GO:0060322 head development GO Biological Processes -11.995356 79 More
GO:0060341 regulation of cellular localization GO Biological Processes -10.5933083 72 More
GO:0060420 regulation of heart growth GO Biological Processes -10.7642352 20 More
GO:0060421 positive regulation of heart growth GO Biological Processes -9.21728400 14 More
GO:0060485 mesenchyme development GO Biological Processes -18.0238 46 More
GO:0060993 kidney morphogenesis GO Biological Processes -5.69627654 15 More
GO:0061180 mammary gland epithelium development GO Biological Processes -3.92752553 10 More
GO:0070372 regulation of ERK1 and ERK2 cascade GO Biological Processes -38.4320790 79 More
GO:0070374 positive regulation of ERK1 and ERK2 cascade GO Biological Processes -34.9831828 64 More
GO:0070848 response to growth factor GO Biological Processes -40.6139195 102 More
GO:0070849 response to epidermal growth factor GO Biological Processes -2.48314997 7 More
GO:0071363 cellular response to growth factor stimulus GO Biological Processes -39.8883675 98 More
GO:0071364 cellular response to epidermal growth factor stimulus GO Biological Processes -2.71044437 7 More
GO:0072001 renal system development GO Biological Processes -17.7796243 52 More
GO:0072006 nephron development GO Biological Processes -8.44009723 23 More
GO:0072028 nephron morphogenesis GO Biological Processes -6.21761544 14 More
GO:0090497 mesenchymal cell migration GO Biological Processes -8.76593708 16 More
GO:0097060 synaptic membrane GO Cellular Components -5.94418548 20 More
GO:0098793 presynapse GO Cellular Components -4.56552653 42 More
GO:0098839 postsynaptic density membrane GO Cellular Components -1.95788592 5 More
GO:0098889 intrinsic component of presynaptic membrane GO Cellular Components -4.93822812 13 More
GO:0098936 intrinsic component of postsynaptic membrane GO Cellular Components -4.76116234 10 More
GO:0098948 intrinsic component of postsynaptic specialization membrane GO Cellular Components -4.56568042 8 More
GO:0098978 glutamatergic synapse GO Cellular Components -4.83590061 31 More
GO:0098984 neuron to neuron synapse GO Cellular Components -1.42277265 10 More
GO:0099055 integral component of postsynaptic membrane GO Cellular Components -4.91964814 10 More
GO:0099056 integral component of presynaptic membrane GO Cellular Components -4.69230219 12 More
GO:0099060 integral component of postsynaptic specialization membrane GO Cellular Components -4.68780123 8 More
GO:0099061 integral component of postsynaptic density membrane GO Cellular Components -2.14492099 4 More
GO:0099146 intrinsic component of postsynaptic density membrane GO Cellular Components -2.05786633 4 More
GO:0099240 intrinsic component of synaptic membrane GO Cellular Components -5.23284212 12 More
GO:0099572 postsynaptic specialization GO Cellular Components -2.67743186 13 More
GO:0099634 postsynaptic specialization membrane GO Cellular Components -4.18233935 9 More
GO:0099699 integral component of synaptic membrane GO Cellular Components -4.78109966 11 More
GO:1903829 positive regulation of protein localization GO Biological Processes -12.9651258 57 More
GO:1904892 regulation of receptor signaling pathway via STAT GO Biological Processes -12.9980471 24 More
KEGG pathways: 3 records
KEGG Description Category LogP Number of genes Detail
hsa04012 ErbB signaling pathway KEGG Pathway -2.03916116 5 More
hsa04020 Calcium signaling pathway KEGG Pathway -10.4415222 36 More
hsa04151 PI3K-Akt signaling pathway KEGG Pathway -29.3006421 73 More
Drug-Gene interaction
view
Related drugs: 33 records
Drug name Interaction type Source PMID View
ac-480 inhibitor TALCMyCancerGenomeTdgClinicalTrialChemblInteractions view
afatinib inhibitor JAX-CKB 27207775 view
afatinib dimaleate inhibitor ChemblInteractions view
alisertib DTC view
azd-1152-hqpa DTC view
bms-690514 inhibitor TALCMyCancerGenomeChemblInteractions view
canertinib dihydrochloride inhibitor ChemblInteractions view
cediranib DTC view
cenisertib DTC view
cetuximab JAX-CKB 27207775 view
chembl578061 DTC view
curcumin DTC 25753330 view
dacomitinib inhibitor TALCMyCancerGenomeTdgClinicalTrialChemblInteractionsMyCancerGenomeClinicalTrial view
dasatinib DTC view
dimethylcurcumin DTC 25753330 view
erlotinib DTCJAX-CKBPharmGKB 27207775 view
gefitinib inhibitor DTCMyCancerGenomeClinicalTrialPharmGKB view
ilorasertib DTC view
jnj-26483327 inhibitor ChemblInteractions view
lapatinib DTCJAX-CKBDoCMCIViCPharmGKB 2559033819718025 view
lauroguadine DTC view
methylcurcumin DTC 25753330 view
osimertinib mesylate inhibitor ChemblInteractions view
paliperidone PharmGKB 25714000 view
pelitinib inhibitor TALCMyCancerGenome view
poziotinib inhibitor ChemblInteractionsMyCancerGenomeClinicalTrial view
r-406 DTC view
rg-1530 DTC view
sb-220025 DTC view
sp-600125 DTC view
tae-684 DTC view
tak-715 DTC view
vandetanib inhibitor ChemblInteractions view
Related study: 1 record
Molecular factor Omics type Application Objective MI type Reference
cg07536926 hypermethylation epigenomics myocardial infarction[diagnosis] myocardial infarction Rask-Andersen M et al. Hum Mol Genet. 2016
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